It is not easy or straight-forward, but when done well it is the most humane. As a rule, it is best to take the rodent to your vet.

Fasteners, ties and clothes will be needed to secure the different containers. The plastic container is the euthanasia chamber for the rodent The plastic bag is the CO2 chamber where the gas is produced.

The ratio of vinegar to baking soda will vary by the size of the container you are using. [2] X Research source Getting the correct concentration of CO2 is key to its humaneness. You want to create a 30%-40% concentration of CO2 in the euthanasia container to cause the rodent to lose consciousness. [3] X Research source

Carbon dioxide exposure that uses a gradual fill method like this is less likely to cause pain. [4] X Research source

The rodent should have a clear path to the trap. The bait should be changed regularly.

This is only envisaged in an emergency situation. Most of the time setting traps in the normal way is preferable to shooting a rodent. [10] X Research source

Even a clean shot will be bloody and distressing.

You should familiarise yourself with local laws before thinking about shooting a rodent.